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Synthesis and biological activity of five-coordinate platinum(II) complexes including organotin fragments
P Carpinelli1, S Bartolucci, F Ruffo
1Dipartimento di Chimica Organica e Biologica, Università di Napoli Federico II, Italy.
Anti-Cancer Drug Design
|January 1, 1995
Abstract:
The synthesis and characterization of two five-coordinate platinum(II) complexes of general formula [PtCl(SnMe(n)Cl3-n)(2,9-Me2-1,10-phenanthroline) (diethylfumarate)] (n = 1, 2) are described. The bimetallic species were tested on the neuroblastoma cell line SK-N-BE and a considerable inhibition of cellular proliferation was detected; the bimetallic species were also able to induce neuronal differentiation, as did retinoic acid, a well-known neuroblastoma differentiating agent.