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Related Experiment Videos

Osteocalcin levels in chronic osteomyelitis

K M Peters1, T Rosendahl, K D Heller

  • 1Department of Orthopaedic Surgery, Rheinisch-Westflische Technische Hochschule Aachen, Germany.

Archives of Orthopaedic and Trauma Surgery
|January 1, 1994
PubMed
Summary
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Serum osteocalcin levels did not change significantly in patients with chronic osteomyelitis undergoing surgery. Therefore, osteocalcin is not a useful marker for managing this bone infection.

Area of Science:

  • Biochemistry
  • Orthopedics
  • Infectious Diseases

Background:

  • Osteocalcin is a vitamin K-dependent bone protein produced by osteoblasts.
  • In general bone conditions, serum osteocalcin reflects osteoblast activity.
  • Chronic osteomyelitis involves bone resorption and formation, influenced by inflammation.

Purpose of the Study:

  • To evaluate the utility of serum osteocalcin as a marker in active chronic osteomyelitis.

Main Methods:

  • Serum levels of osteocalcin, alkaline phosphatase, and C-reactive protein were measured in 17 patients.
  • Measurements were taken before surgery, in the early postoperative period, and at discharge.

Main Results:

  • Preoperative osteocalcin levels were within the normal range (10.8 +/- 11.0 micrograms/l).

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  • Osteocalcin levels remained normal postoperatively and at discharge.

    • Conclusions:

    • Serum osteocalcin is not a helpful marker for the clinical management of chronic osteomyelitis.