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V beta-specific immunotoxin selectively kills acetylcholine receptor-reactive T lymphocytes from mice with
P A Thompson1, R McAtee, A J Infante
1Department of Microbiology, University of Texas Health Science Center at San Antonio 78284.
Abstract:
Immunization of C57BL/6 mice with purified acetylcholine receptor (AChR) is known to induce a T cell-dependent antibody response that results in experimental autoimmune myasthenia gravis (EAMG). Since past observations link V beta 6+ T cells with a prominent AChR epitope specificity, a V beta 6-specific immunotoxin (VIT6) was tested in vitro for its ability to selectively kill monoclonal and polyclonal T cells that demonstrate reactivity against AChR. Results described below clearly demonstrate the ability to selectively kill AChR-reactive T cells based on their expression of a particular V beta-associated antigen receptor.