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cDNA cloning of a thromboxane A2 receptor from rat astrocytes
J Kitanaka1, H Hashimoto, Y Sugimoto
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Biochimica Et Biophysica Acta
|March 16, 1995
Abstract:
A cDNA clone for rat thromboxane (TX) A2 receptor was obtained from cultured astrocytes. The cDNA encodes a protein of 341 amino acids with seven putative transmembrane domains. The receptor is homologous with mouse and human TXA2 receptors at 92.7% and 71.8%, respectively. Expression of messenger RNA for the receptor was examined by reverse transcriptase-polymerase chain reaction, showing ubiquitous expression in brain glial cells such as astrocytes, oligodendrocytes and microglia.