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Simple assay for 5-fluorocytosine in the presence of amphotericin B
Antimicrobial Agents and Chemotherapy
|March 1, 1976
Abstract:
A simple method for the measurement of 5-fluorocytosine in the presence of amphotericin B is described. The antifungal activity of amphotericin B is abolished by heating serum at 100 C for 45 min. 5-Fluorocytosine is unaffected by this treatment, and serum levels can be subsequently assayed by either tube dilution or disk diffusion methods.
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