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Hematological reference ranges among healthy Ugandans

S B Tugume1, E M Piwowar, T Lutalo

  • 1Joint Clinical Research Centre, Makerere University Medical School, Kampala, Uganda.

Clinical and Diagnostic Laboratory Immunology
|March 1, 1995
PubMed
Summary

Hematologic reference ranges were established for Ugandan adults. These ranges, including absolute lymphocyte, CD4, and CD8 counts, differ from those in other populations, highlighting the need for localized data.

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Area of Science:

  • Hematology
  • Immunology
  • Public Health

Background:

  • Hematologic reference values are crucial for accurate interpretation in clinical practice and research.
  • Establishing population-specific reference ranges is vital for effective healthcare and scientific studies.

Purpose of the Study:

  • To determine the hematological reference ranges for symptom-free, human immunodeficiency virus antibody-negative adults in Uganda.
  • To compare these ranges with those reported for populations outside of Africa.

Main Methods:

  • A study was conducted on 183 Ugandan adults (aged 15-74 years).
  • Blood samples were analyzed to establish central 95% distribution curves for key hematologic parameters.
  • Demographic data, including sex and age, were collected and analyzed.

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Main Results:

  • Established reference ranges include: absolute lymphocyte count (1,453–4,448 cells/µL), absolute CD4 count (559–2,333 cells/µL), absolute CD8 count (253–1,396 cells/µL), and CD4/CD8 ratio (0.68–4.4).
  • Women exhibited significantly higher mean absolute lymphocyte counts, absolute CD4 counts, and CD4/CD8 ratios compared to men.
  • The derived hematological reference ranges were found to differ from those previously reported for non-African populations.

Conclusions:

  • The established hematological reference ranges are specific to the Ugandan adult population studied.
  • These findings underscore the importance of utilizing localized reference ranges for accurate hematologic data interpretation in Uganda.
  • The observed sex-based differences in hematologic parameters warrant further investigation.