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Might migraine damage the brain?

E Chronicle1, W Mulleners

  • 1Department of Psychology, Lancaster University, UK.

Cephalalgia : an International Journal of Headache
|December 1, 1994
PubMed
Summary
This summary is machine-generated.

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Migraine with aura may cause long-term neuronal damage, particularly in the visual cortex, due to reduced cerebral blood flow during attacks. This damage may selectively affect specific inhibitory neurons.

Area of Science:

  • Neurology
  • Neuroscience
  • Cerebrovascular Medicine

Background:

  • Debate exists regarding regional cerebral blood flow (rCBF) changes during migraine with aura.
  • Cerebral ischemia during migraine attacks is a recognized phenomenon.

Purpose of the Study:

  • To propose that cerebral ischemia during migraine with aura attacks may lead to long-term neuronal damage.
  • To hypothesize that this damage may occur in the primary visual cortex.

Main Methods:

  • Review of recent high-resolution rCBF studies in migraine with aura.
  • Examination of animal models of hypoxic neuronal vulnerability.
  • Analysis of recent studies on visual function in migraine patients.

Main Results:

Related Experiment Videos

  • rCBF reductions in migraine with aura attacks may be confined to the primary visual cortex.
  • The degree of rCBF reduction may selectively damage GABA-ergic inhibitory interneurons in layer IV.
  • Animal models show similar cells are vulnerable to hypoxia.

Conclusions:

  • Migraine with aura-associated ischemia could cause long-term neuronal damage.
  • The primary visual cortex and its GABA-ergic interneurons are potential targets.
  • Further investigation into clinical and pathophysiological implications is warranted.