Hereditary cerebellar vermis defect in the Lewis rat
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M Kuwamura1, T Yoshida, J Yamate
1Department of Veterinary Pathology, College of Agriculture, University of Osaka Prefecture, Japan.
Brain Research. Developmental Brain Research
|December 16, 1994
Abstract:
We report a new rat model of hereditary cerebellar vermis defect. Mutant rats exhibited hind-leg paralysis from about 14 days old. Gross pathology showed the cerebellar vermis defect, fused cerebellar hemispheres and cyst formation. Ectopic dysplastic cerebellar tissues existed in the cerebello-pontine junctional zones. Mild disarrangement of lamination was also observed in the fused cerebellar hemispheres. The present mutant may serve as a valid model for studying the cerebellar vermis defect under the genetic control.