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Antimycobacterial susceptibility testing: present practices and future trends

C B Inderlied1

  • 1Department of Pathology, University of Southern California, Los Angeles, USA.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|November 1, 1994
PubMed
Summary

Mycobacterial susceptibility testing is crucial for managing infections, especially in HIV patients. New testing methods are needed to evaluate novel antimycobacterial agents effectively.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Diagnostics

Background:

  • Renewed global interest in tuberculosis and non-tuberculous mycobacterial infections.
  • High incidence of mycobacterial diseases in HIV-infected individuals.
  • Need for effective management of infections caused by rapidly growing mycobacteria.

Purpose of the Study:

  • To review current practices in mycobacterial susceptibility testing.
  • To assess the need for updated methods for novel antimycobacterial agents.
  • To explore the future potential of mycobacterial susceptibility testing.

Main Methods:

  • Overview of conventional susceptibility testing methods (e.g., proportion method).
  • Discussion of limitations of existing methods for new antimicrobial agents.

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  • Exploration of emerging mycobacterial susceptibility testing technologies.

    • Main Results:

    • Conventional methods may not be adequately validated for new antimycobacterial drugs.
    • Newer testing methods offer potential advantages over traditional approaches.
    • Increased understanding of mycobacterial pathobiology and drug pharmacokinetics.

    Conclusions:

    • Current mycobacterial susceptibility testing practices may require re-evaluation.
    • Development and validation of new susceptibility testing methods are essential.
    • Advancements in understanding and technology will shape future antimycobacterial drug development and patient care.