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Multiple arteriovenous malformations in a man with a connective tissue disorder
1Department of Cardiology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
European Heart Journal
|December 1, 1994
Summary
Multiple arteriovenous malformations are rarely seen in connective tissue disorders. This case highlights a patient with features of a connective tissue disorder and multiple arteriovenous malformations, leading to significant health issues.
Area of Science:
- Vascular Medicine
- Genetics
- Rheumatology
Background:
- Connective tissue disorders (CTDs) are a group of inherited conditions affecting the body's connective tissues.
- While vascular manifestations are known in some CTDs, multiple arteriovenous malformations (AVMs) are not a commonly reported association.
Observation:
- A male patient presented with cutaneous, ligament/articular, and vascular features indicative of a connective tissue disorder.
- This patient also exhibited multiple arteriovenous malformations.
Findings:
- The multiple AVMs led to a high-output circulatory state.
- Subclavian artery-originating AVMs caused significant morbidity, including chest pain.
Implications:
- This case expands the known clinical spectrum of connective tissue disorders.
- It underscores the importance of considering AVMs in patients with undiagnosed connective tissue abnormalities.
- Further research may elucidate sharedPathways between CTDs and vascular malformations.
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