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Controlled ovarian hyperstimulation with or without intrauterine insemination for the treatment of unexplained
O Gregoriou1, N Vitoratos, C Papadias
12nd Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.
Objective:
To evaluate whether there are any benefits from intrauterine insemination (IUI) as opposed to timed intercourse (TI) in stimulated ovarian cycles in couples with longstanding, unexplained infertility.
Methods:
Forty-six couples with diagnoses of unexplained infertility were evaluated in a crossover study after a total of 141 cycles. Sixty-seven cycles were with IUI after controlled ovarian hyperstimulation (COH) while 74 cycles were after COH and TI.
Results:
The pregnancy rate after COH/TI was 16.7% and after COH/IUI 45.2%. Cycle fecundity however was 8.9% after COH/TI and 25.7% after COH/IUI, which is a statistically significant difference (P < 0.05).
Conclusions:
A trial of human menopausal gonadotropin and IUI is justified in couples with prolonged infertility of unknown cause.