[Topography of the neurons producing LRF in primates]

Specifically immunoreactive perikarya have been found in the hypothalamus of normal monkeys, using antisera to synthetic LRF. These perikarya are mainly localized in the medio-basal hypothalamus. The majority of their axons form a "tubero-infundibular LRF tract", with a very complex preterminal pattern. Some specifically immunoreactive axons seem to belong to "extra-hypophyseal LRF pathways", having in part telencephalic or mesencephalic terminations.