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[Lysosomal system in hormonal mechanisms. Review]
G Duran Reyes1, G González Macías, J J Hicks
1Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Instituto Mexicano del Seguro Social.
Ginecologia Y Obstetricia De Mexico
|February 1, 1995
Summary
Hormones trigger cellular changes, moving lysosomes toward the nucleus to release enzymes. Inhibiting this lysosome action disrupts reproductive processes like egg implantation.
Area of Science:
- Cell Biology
- Endocrinology
- Reproductive Biology
Background:
- Lysosomes play a crucial role in intracellular mechanisms.
- Hormone action involves complex cellular signaling pathways.
Purpose of the Study:
- To review the role of lysosomes in the mechanism of action of steroid and protein hormones.
- To explore the involvement of lysosomes in reproductive processes.
Main Methods:
- Review of existing literature on hormone action and lysosome function.
- Analysis of cellular and molecular mechanisms.
Main Results:
- Hormone presence induces target cell membrane changes and lysosome migration towards the nucleus.
- Lysosomal enzymes are released into the perinuclear space.
- Inhibition of lysosome movement blocks reproductive processes such as mammalian egg implantation.
Conclusions:
- Lysosomes are integral to the intracellular action of certain hormones.
- Lysosome-mediated mechanisms are critical for successful reproduction.