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Syringolymphoid hyperplasia with alopecia. A case report
M M Tomaszewski1, G P Lupton, J Krishnan
1Department of Dermatopathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000.
Journal of Cutaneous Pathology
|December 1, 1994
Summary
Syringolymphoid hyperplasia with alopecia is a rare skin condition. This case study details a patient with persistent hairless patches, revealing characteristic eccrine gland changes and T-cell infiltrates.
Area of Science:
- Dermatology
- Pathology
Background:
- Syringolymphoid hyperplasia with alopecia (SLHA) is an uncommon skin disorder.
- First described in 1969, only a few cases have been reported globally.
Observation:
- A 59-year-old man presented with long-standing, hyperpigmented, hairless skin patches.
- Biopsy revealed hyperplasia of eccrine glands and ducts with lymphocytic infiltration ('syringotropism').
Findings:
- The lymphocytic infiltrate showed T helper cell phenotype with gene rearrangement.
- Associated findings included perifollicular infiltration, follicular mucinosis, and features suggestive of mycosis fungoides.
Implications:
- This case expands the understanding of SLHA's clinical and histopathological spectrum.
- Highlights the importance of comprehensive immunophenotyping and gene studies in diagnosing rare dermatoses.