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Elevated plasma stromelysin levels in arthritis
S Zucker1, R M Lysik, M H Zarrabi
1Department of Veterans Administration Medical Center, Northport, NY 11768.
The Journal of Rheumatology
|December 1, 1994
Summary
Plasma stromelysin-1 levels are elevated in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), suggesting its potential as a diagnostic marker for arthritis. Gelatinase A levels did not show significant changes.
Area of Science:
- Biochemistry
- Immunology
- Rheumatology
Background:
- Matrix metalloproteinases (MMPs) play a role in tissue remodeling and inflammation.
- Stromelysin-1 (MMP-3) and gelatinase A (MMP-2) are MMPs implicated in joint diseases.
- Elevated MMPs in synovial fluid are observed in inflammatory arthritis.
Purpose of the Study:
- To investigate plasma concentrations of stromelysin-1 and gelatinase A in patients with various forms of arthritis.
- To assess the diagnostic potential of these MMPs in arthritis.
Main Methods:
- Sandwich enzyme-linked immunosorbent assay (ELISA) was employed to measure plasma stromelysin-1 and gelatinase A.
- Study included healthy subjects, patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), osteoarthritis (OA), gout, and cancer.
Main Results:
- Plasma stromelysin-1 was significantly elevated in patients with RA and SLE compared to healthy controls and cancer patients.
- Elevated stromelysin-1 was also observed in patients with OA and gout.
- Plasma gelatinase A levels were not significantly increased in patients with RA, OA, or gout.
Conclusions:
- Elevated plasma stromelysin-1 in RA patients aligns with increased levels in inflamed synovial tissue.
- Plasma stromelysin-1 measurement may aid in the diagnosis and management of arthritis.
- The source of increased plasma stromelysin-1 in SLE requires further investigation.