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Related Experiment Videos

Radiologic features of systemic onset juvenile rheumatoid arthritis

B A Lang1, R Schneider, B J Reilly

  • 1Department of Pediatrics, Izaak Walton Killam Children's Hospital, Dalhousie University, Halifax, NS, Canada.

The Journal of Rheumatology
|January 1, 1995
PubMed
Summary

Systemic onset juvenile rheumatoid arthritis (SOJRA) can cause early and severe joint damage, including erosions and ankylosis. Early subchondral changes may predict future erosive disease in children with SOJRA.

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Area of Science:

  • Pediatric Rheumatology
  • Radiology
  • Medical Imaging

Background:

  • Systemic onset juvenile rheumatoid arthritis (SOJRA) is a severe form of juvenile idiopathic arthritis.
  • Radiographic manifestations of SOJRA are not fully characterized, especially early in the disease course.

Purpose of the Study:

  • To document the spectrum of radiologic abnormalities in patients with SOJRA.
  • To identify early radiologic signs and their progression over time.

Main Methods:

  • Retrospective review of medical charts and radiographs from 42 children with SOJRA.
  • Radiographs were analyzed by a single radiologist blinded to clinical data.

Main Results:

  • Soft tissue swelling and osteoporosis were most common (81%).

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  • Cartilage loss and erosions occurred in 50% of patients, with erosions appearing within 2 years in 31%.
  • Severe findings included ankylosis (19%), subluxation (21%), and protrusio acetabuli (10%).

    • Conclusions:

    • SOJRA can lead to early destructive radiologic changes comparable to rheumatoid factor-positive polyarticular JRA.
    • Early subchondral changes may predict subsequent erosive disease, warranting further investigation with advanced imaging techniques.