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[Establishment and usage of human multiple myeloma cell line]
H Hattori1, S Tagawa, T Kitani
1Department of Hematology and Oncology, Osaka University Medical School.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 1, 1995
Summary
This review lists plasma cell malignancy (MPC) cell lines, finding successful establishment correlates with extra-medullary invasion in multiple myeloma (MM). It also explores MPC cell line applications in research, aiding future plasmacytology development.
Area of Science:
- Hematology
- Oncology
- Cell Biology
Context:
- Plasma cell malignancies (MPC) encompass multiple myeloma (MM), plasmacytoma, and plasma cell leukemia.
- Understanding MPC cell lines is crucial for advancing research in these hematologic cancers.
Purpose:
- To compile a comprehensive list of reported plasma cell malignancy (MPC) cell lines.
- To review the established uses and applications of MPC cell lines in scientific research.
Summary:
- Successful establishment of MPC cell lines appears linked to using cells from patients with extra-medullary invasion in multiple myeloma (MM).
- Interleukin-6 (IL-6) dependent cell lines may arise independently of cell origin.
- The review examines seven key research areas involving MPC cell lines, including proliferation, cytokine influence, human MM models, chromosomal abnormalities, fibronectin interactions, osteoblast activating factor (OAF), and tumor aberrations.
Impact:
- This compilation and review are expected to advance the field of plasmacytology.
- Provides a foundation for future research into the biology and treatment of plasma cell malignancies.