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Updated: Sep 10, 2026
Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
[Coronary angiography (including PTCA)]
11st Department of Internal Medicine, Yamagata University, School of Medicine.
Insights
Coronary arteriography (CAG) is a gold standard for diagnosing ischemic heart disease (IHD). This review discusses lesion classification, progression/regression, and pitfalls, incorporating newer modalities like IVUS for plaque characterization.
Area of Science:
- Cardiology
- Diagnostic Imaging
- Medical Research
Background:
- Coronary arteriography (CAG) is a gold standard for diagnosing ischemic heart disease (IHD).
- Understanding coronary lesion characteristics is crucial for IHD management.
- Serial CAG allows assessment of lesion progression and regression.
Purpose of the Study:
- To review the characterization of focal coronary lesions using CAG.
- To discuss classifications (Rosch's, AHA) and pitfalls in evaluating coronary stenosis.
- To highlight recent advancements in plaque assessment using IVUS and angioscopy.
Main Methods:
- Review of existing literature on coronary arteriography and lesion classification.
- Discussion of serial CAG for assessing lesion changes.
- Inclusion of information on intravascular ultrasound (IVUS) and angioscopy for plaque characterization.
Main Results:
- CAG provides a gold standard for IHD diagnosis and lesion severity assessment.
- Rosch's and AHA classifications aid in characterizing coronary lesions.
- Serial CAG can reveal progression or regression of atherosclerotic lesions.
- IVUS and angioscopy offer detailed insights into plaque composition (soft, hard, calcification) and intimal thickening.
Conclusions:
- CAG remains a cornerstone for IHD diagnosis, with established classification systems.
- Serial CAG is valuable for monitoring atherosclerotic lesion dynamics.
- Advanced imaging modalities like IVUS and angioscopy enhance the understanding of coronary plaque characteristics, aiding in risk stratification and treatment decisions.
Abstract:
Coronary arteriography (CAG) is one of the gold standards for diagnosing the severity of ischemic heart disease (IHD). Characterization of the angiographic findings of the focal coronary lesion was discussed on the basis of Rosch's and American Heart Association (AHA) classification. Recently, progression and regression of coronary atherosclerotic lesions have been assessed by serial CAG. Regression was believed to result from the dissolution or remodeling of thrombus or from the removal of plaque lipid and cellular elements. Accordingly, we also discussed the pitfalls in the evaluation of coronary stenosis. Recent modalities including intravascular ultrasound (IVUS) and angioscopy have been applied to assess the maternal characteristics of coronary atherosclerotic lesions, such as soft plaque, hard plaque, and calcification along with the extent of intimal thickening.
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