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Effects of cilazapril on cardiac structure and function in hypertension
V S Moisejev1, A Y Ivleva, A B Gurochkin
1Department of Internal Medicine and Clinical Pharmacology, Russian Peoples' Friendship University, Moscow.
Insights
Cilazapril treatment in essential hypertension patients significantly improved cardiac function, reducing left ventricular mass and enhancing diastolic filling patterns. This vasodilator therapy offers a promising approach for managing hypertension-related cardiac changes.
Area of Science:
- Cardiology
- Pharmacology
- Hypertension Research
Background:
- Systemic hypertension is linked to increased peripheral vascular resistance, elevated arterial blood pressure, and left ventricular hypertrophy (LVH).
- Hypertension-induced LVH is associated with altered systolic and diastolic cardiac function, detectable via echocardiography.
Purpose of the Study:
- To investigate the effects of cilazapril, a vasodilator, on cardiac structure and function in patients with essential hypertension.
- To assess the impact of cilazapril monotherapy on left ventricular mass, isovolumic relaxation time, and diastolic filling patterns.
Main Methods:
- A study involving 23 essential hypertension patients treated with 2.5-5 mg of cilazapril daily for six months.
- Echocardiography was used to measure hemodynamic changes, left ventricular mass, and diastolic function parameters.
Main Results:
- Cilazapril treatment led to a significant reduction in left ventricular mass.
- Improvements were observed in the early diastolic filling pattern, isovolumic relaxation time, and the left ventricular early/atrial filling ratio.
Conclusions:
- Cilazapril monotherapy effectively reduces left ventricular mass in hypertensive patients.
- The vasodilator demonstrates significant improvements in diastolic cardiac function, offering a therapeutic benefit for managing hypertension-related cardiac remodeling.
Abstract:
Peripheral vascular resistance, arterial blood pressure, and left ventricular hypertrophy (LVH) are closely related. In systemic hypertension, hemodynamic changes in systolic and diastolic function accompany LVH. Both of these cardiac functions are detected with echocardiography and were measured during this study in 23 essential hypertension patients treated with 2.5-5 mg of cilazapril daily for 6 months. Reduction in left ventricular mass was accompanied by an improvement in early diastolic filling pattern. This change in cardiac performance with cilazapril vasodilator monotherapy was characterized by a significant improvement in isovolumic relaxation time and normalized left ventricular early/atrial filling ratio.