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Tissue-type plasminogen activator (tPA) is the main plasminogen activator associated with isolated rat nerve growth
M García-Rocha1, J Avila, R Armas-Portela
1Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
Neuroscience Letters
|October 24, 1994
Abstract:
Different studies in tissue culture have shown the involvement of plasminogen activators (PAs) in nerve growth-cone migration. We have studied PA activity associated with isolated rat brain growth cones. Fibrin-agarose zymographies show that tissue-type PA (tPA) is the main PA associated with these structures. After fractionation of growth cones, a slightly higher tPA activity was found associated with the particulate fraction. The present findings support the requirement of this protease for neurite growth.