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Related Experiment Videos

Platelet aggregation and dense granule secretion in schizophrenia

J K Yao1, D P van Kammen, J Gurklis

  • 1Neurochemistry and Psychopharmacology Laboratory, Highland Drive Department of Veterans Affairs Medical Center (DVAMC), Pittsburgh, PA, USA.

Psychiatry Research
|October 1, 1994
PubMed
Summary

Schizophrenia patients exhibit altered platelet aggregation and adenosine triphosphate (ATP) release, suggesting impaired platelet function. These changes correlate with psychosis severity but not medication levels.

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Area of Science:

  • Neuroscience
  • Hematology
  • Psychiatry

Background:

  • Platelet function may be altered in schizophrenia.
  • Antipsychotic medications could influence platelet activity.

Purpose of the Study:

  • To investigate platelet aggregation and adenosine triphosphate (ATP) release in schizophrenic patients.
  • To compare platelet function between treated and untreated schizophrenic patients and healthy controls.
  • To explore correlations between platelet function and clinical parameters.

Main Methods:

  • Assessed platelet aggregation and ATP release in response to collagen, arachidonic acid (AA), and adenosine diphosphate (ADP).
  • Compared functional states in normal controls, haloperidol-treated schizophrenic patients, and drug-free schizophrenic patients.

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  • Correlated platelet function with psychosis ratings, medication dosage, and illness duration.

    • Main Results:

    • Platelet aggregation was higher in both patient groups compared to controls (collagen-induced).
    • AA-induced ATP release was lower in haloperidol-treated patients versus controls.
    • ATP release was higher in drug-free patients than when they were on haloperidol.
    • Collagen-induced platelet function correlated negatively with psychosis ratings.

    Conclusions:

    • Schizophrenia is associated with distinct alterations in platelet function, including impaired ATP release.
    • Haloperidol treatment may affect platelet adenosine triphosphate (ATP) secretion.
    • Platelet dysfunction in schizophrenia correlates with psychosis severity, independent of medication dosage or illness duration.