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A meta-analysis of clinical trials involving different classifications of response into ordered categories
1Department of Applied Statistics, The University, Whiteknights, Reading, U.K.
Abstract:
Statistical methods are available for performing a meta-analysis when the response variable of interest is the same in each study. Problems arise when studies exploring a common therapeutic question use different patient response types. This article presents statistical methods for combining studies which involve different classifications of response into ordered categories. The assumptions required for the stratified proportional odds model, on which the analysis is based, are discussed. The approach is illustrated using results from a series of studies investigating the prevention of gastrointestinal damage induced by non-steroidal anti-inflammatory drugs.