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Motor dysfunction during sleep in posttraumatic stress disorder

R J Ross1, W A Ball, D F Dinges

  • 1Research Service, Philadelphia Veterans Affairs Medical Center, Pennsylvania 19104.

Sleep
|December 1, 1994
PubMed
Summary
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Posttraumatic stress disorder (PTSD) may involve REM sleep dysfunction, with patients exhibiting increased muscle activity during sleep. This suggests REM sleep disturbances are linked to PTSD, similar to REM behavior disorder (RBD).

Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Psychiatry

Background:

  • Posttraumatic stress disorder (PTSD) is characterized by sleep disturbances, including anxiety dreams.
  • The nature of PTSD anxiety dreams suggests a potential dysfunction in rapid eye movement (REM) sleep.
  • Normal REM sleep involves muscle atonia, contrasting with reported motor activity during PTSD dreams.

Purpose of the Study:

  • To investigate the discrepancy between normal REM sleep atonia and reported motor activity in PTSD dreams.
  • To examine muscle activity during sleep in Vietnam combat veterans with PTSD compared to controls.
  • To explore potential REM sleep phasic mechanism disturbances in PTSD.

Main Methods:

  • Studied anterior tibialis muscle activity during sleep in PTSD subjects and a control group.

Related Experiment Videos

  • Compared REM sleep epochs for prolonged twitch bursts between groups.
  • Assessed the occurrence of periodic limb movements during non-REM sleep.

    • Main Results:

    • PTSD subjects showed a higher percentage of REM sleep epochs with prolonged twitch bursts.
    • PTSD subjects were more likely to experience periodic limb movements during non-REM sleep.
    • These muscle activation patterns resemble those seen in REM behavior disorder (RBD).

    Conclusions:

    • The findings suggest a fundamental disturbance of REM sleep phasic mechanisms in PTSD.
    • The presence of RBD-like signs in PTSD strengthens the link between PTSD and REM sleep dysfunction.
    • This research contributes to understanding the neurobiological underpinnings of sleep disturbances in PTSD.