Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paradoxical sleep mechanisms

M Jouvet1

  • 1Department of Experimental Medicine, Claude Bernard University, Lyon, France.

Sleep
|December 1, 1994
PubMed
Summary

The pons is not essential for paradoxical sleep (PS) generation. PS rebound can depend on stress from PS deprivation, and PS requires glucose metabolism, potentially increasing with hyperoxia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of the lateral preoptic area in sleep-related erectile mechanisms and sleep generation in the rat.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2000
Same author

Effect of noradrenergic denervation of the amygdala upon recovery after sleep deprivation in the rat.

Neuroscience letters·2000
Same author

Tyrosine hydroxylase and aromatic L-amino acid decarboxylase do not coexist in neurons in the human anterior cingulate cortex.

Neuroscience letters·2000
Same author

Differential c-fos expression in the rhinencephalon and striatum after enhanced sleep-wake states in the cat.

The European journal of neuroscience·2000
Same author

Effects of amphetamine and modafinil on the sleep/wake cycle during experimental hypersomnia induced by sleep deprivation in the cat.

Journal of sleep research·2000
Same author

Cholinergic neurons with monoamine oxidase type B (MAOB)-activity in the laterodorsal tegmental nucleus of the mouse.

Neuroscience letters·1999

Area of Science:

  • Neuroscience
  • Sleep Science

Background:

  • Paradoxical sleep (PS), also known as REM sleep, is a critical stage of sleep.
  • Understanding the neurobiological underpinnings of PS generation and rebound is crucial for sleep research.

Purpose of the Study:

  • To review evidence regarding the necessity and sufficiency of the pons for paradoxical sleep generation.
  • To summarize theories explaining paradoxical sleep rebound mechanisms.
  • To investigate factors influencing paradoxical sleep, including stress and metabolic conditions.

Main Methods:

  • Review of existing literature on brain-stem transections, carbachol microinjections, and lesions.
  • Analysis of studies examining paradoxical sleep rebound.
  • Examination of metabolic and environmental factors affecting paradoxical sleep.

Main Results:

  • Evidence does not support the pons as being necessary and sufficient for paradoxical sleep generation.
  • Paradoxical sleep rebound can be influenced by the stressful nature of paradoxical sleep deprivation.
  • Paradoxical sleep appears to depend on oxidative glucose metabolism and may be enhanced by hyperoxia.

Conclusions:

  • The pons's role in paradoxical sleep generation is not definitively established as necessary and sufficient.
  • Stressful paradoxical sleep deprivation can trigger paradoxical sleep rebound.
  • Metabolic factors, particularly glucose oxidation and oxygen levels, may modulate paradoxical sleep.

Related Experiment Videos