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Disappearing bone disease: a case report

B A Kareem1, P K Das, R Saad

  • 1Department of Orthopaedics, Hospital Universiti Sains Malaysia, Kelantan.

Singapore Medical Journal
|October 1, 1994
PubMed
Summary

Disappearing bone disease, a rare condition, caused rapid, extensive osteolysis in a pediatric patient. Despite treatment, the disease progressed fatally, highlighting its aggressive nature in this young individual.

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Area of Science:

  • Orthopedics
  • Pediatric Endocrinology

Background:

  • Disappearing bone disease (DBD) is a rare condition with unknown etiology, typically affecting young adults.
  • This report details a unique pediatric case of DBD.

Observation:

  • A 12-year-old female sustained a femur fracture, leading to extensive, progressive osteolysis.
  • The osteolysis spread to the contralateral pelvic girdle and femur over 3.5 years.

Findings:

  • Calcitonin treatment showed no improvement in the extensive bone loss.
  • Rapid, aggressive progression of DBD in a pediatric patient was observed.

Implications:

  • This case highlights the potential for rapid, fatal progression of DBD, even in pediatric patients.
  • Further research into the etiology and effective treatments for aggressive DBD is warranted.

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