[Study of the effect of centrophenoxine on experimental animals poisoned with chlordiazepoxide]

The author administered per os chlordiazepoxide in a toxic dose of 600 mg/kg of body weight/LD50 of chloridazenoxide for rats was 680 mg/kg of body weight in 20 white male rats, weighing 150 gm. Two hours later, on the background of advanced intoxication, manifested by adynamia ataxia, lateral position, somnolence reaching stupor, the author administered in half of the animals (10) per os centrophenaxine in a dose of 50 mg/kg of body weight. The signs of intoxication disappeared for 24 hours after treatment with centrophenoxine. Three of the control animals died, but in the remaining rats the intoxication worsened, but then slowly disappeared till the end of the fifth day. The obtained experimental data supported the observations of the clinical practice on the favourable effect of centrophenoxine in the treatment of acute poisonings with chlordiazepoxide.