[Two cases of multiple evanescent white dot syndrome examined with indocyanine green angiography]

Two cases of multiple evanescent white dot syndrome (MEWDS) were examined using indocyanine green angiography. Patients were 32 and 45 years old. Both were female. Fluorescein angiography demonstrated early hyperfluorescence corresponding to the white dots. The early phase of indocyanine green angiography showed no abnormal signs, but the late phase disclosed hypofluorescent lesions corresponding to the white dots and even other areas. Each hypofluorescent lesion was punctate and patchy in some areas. The white dots began to fade and returned to the normal color of the fundus from the center to the edge of the lesion. In indocyanine green angiography, the hypofluorescent lesions began to show a normal appearance at the center of the lesion. The indocyanine green angiogram was normal after the white dots had disappeared. The origin of hypofluorescence in indocyanine green angiography was unknown. However, the findings suggest that MEWDS may affect the choroid as well as the retinal pigment epithelium and photoreceptors.