Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac function and hematocrit level

J D Harnett1, G M Kent, R N Foley

  • 1Division of Nephrology, Memorial University, St John's, Canada.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Melt focusing along lithosphere-asthenosphere boundary below Axial volcano.

Nature·2025
Same author

Renal Consequences of Diabetes After Kidney Donation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Evaluation of a population-based approach to familial colorectal cancer.

Clinical genetics·2016
Same author

The effects of cinacalcet on blood pressure, mortality and cardiovascular endpoints in the EVOLVE trial.

Journal of human hypertension·2015
Same author

Influence of pre-diagnostic cigarette smoking on colorectal cancer survival: overall and by tumour molecular phenotype.

British journal of cancer·2014
Same author

Associations of baseline characteristics with evolution of eGFR in a referred chronic kidney disease cohort.

QJM : monthly journal of the Association of Physicians·2013
Same journal

Approach to Hyperkalemia: The Role of Diet and Pharmacological Therapies.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

High Protein Diets: What to Tell Our Patients.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Progressive Kidney Dysfunction and Ocular Clues: A Quiz.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Influence of Lactate Dehydrogenase on the Measurement of Blood Bicarbonate.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Urinary CXCL9 and CXCL10, Interstitial Inflammation and Disease Activity Over Time in Acute Interstitial Nephritis.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Hemophagocytic Lymphohistiocytosis and Fibroblast Growth Factor 23 (FGF23)-Induced Hypophosphatemia.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
See all related articles

Anemia in dialysis patients significantly increases mortality risk and the likelihood of developing congestive heart failure. Early detection and management of anemia are crucial for improving outcomes in this population.

Area of Science:

  • Nephrology
  • Cardiology
  • Hematology

Background:

  • Patients undergoing dialysis face a significantly higher mortality rate compared to the general population, with cardiovascular disease being the primary cause.
  • Anemia is a common complication in patients on dialysis, often associated with poor clinical outcomes.

Purpose of the Study:

  • To investigate the independent association between anemia and mortality in patients on dialysis.
  • To determine if anemia predicts the occurrence and recurrence of congestive heart failure in this cohort.
  • To identify risk factors for left ventricular hypertrophy (LVH) in end-stage renal disease (ESRD) patients.

Main Methods:

  • Prospective cohort study involving 433 patients across three dialysis centers.
  • Follow-up duration averaged 41 months.

Related Experiment Videos

  • Cox's regression modeling was employed to assess the independent predictive value of hemoglobin levels on mortality and heart failure, controlling for various clinical and echocardiographic factors.

    • Main Results:

    • Anemia independently predicted mortality (RR 1.18 per 1.0 g/dL decrease in hemoglobin).
    • Anemia was also an independent predictor of new-onset congestive heart failure (RR 1.49), heart failure at dialysis initiation (RR 1.14), and heart failure recurrence (RR 1.25).
    • Increasing age, hypertension, and anemia were identified as risk factors for left ventricular hypertrophy, which itself independently predicts mortality.

    Conclusions:

    • Anemia is a significant independent risk factor for mortality and congestive heart failure in patients on dialysis.
    • Management of anemia may be critical for improving cardiovascular outcomes in ESRD patients.
    • Recombinant human erythropoietin (epoetin) has shown potential in improving left ventricular mass in some studies.