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In utero brachial artery thrombosis: limb salvage with postnatal urokinase infusion
E Ricciardelli1, R F Morgan, K Y Lin
1Department of Plastic Surgery and Orthopedics, University of Virginia Health Sciences Center, Charlottesville 22908.
Annals of Plastic Surgery
|January 1, 1995
Abstract:
In utero brachial artery thrombosis leading to neonatal extremity gangrene can occur from a variety of causes. Traditional management has been limited to supportive care, often leading to early amputation. We report a case of a 1-day-old neonate who presented with an in utero brachial artery thrombosis and whose treatment consisted of early, aggressive systemic thrombolytic therapy followed by serial soft-tissue debridement and ultimate skin coverage through cultured epithelial autografts. This resulted in a successfully salvaged and partially functional upper extremity.