Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How many receptors does it take?

K A Wharton1

  • 1Division of Biology and Medicine, Brown University, Providence, RI 02912.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|January 1, 1995
PubMed
Summary

Two genes, thick veins (tkv) and saxophone (sax), encode receptors for Drosophila TGF-beta signaling. Tkv patterns the dorsal region, while sax patterns the dorsalmost cell fates, with both genes crucial for dpp signaling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The MuSK-BMP pathway regulates synaptic Nav1.4 localization and muscle excitability.

bioRxiv : the preprint server for biology·2023
Same author

Compartment specific mitochondrial dysfunction in Drosophila knock-in model of ALS reversed by altered gene expression of OXPHOS subunits and pro-fission factor Drp1.

Molecular and cellular neurosciences·2023
Same author

Context-dependent relationships between the BMPs gbb and dpp during development of the Drosophila wing imaginal disk.

Development (Cambridge, England)·2001
Same author

Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling.

Developmental biology·2001
Same author

Twisted perspective: new insights into extracellular modulation of BMP signaling during development.

Cell·2001
Same author

Naked cuticle targets dishevelled to antagonize Wnt signal transduction.

Genes & development·2001

Area of Science:

  • Developmental biology
  • Genetics
  • Molecular signaling

Background:

  • Transforming growth factor-beta (TGF-beta) signaling pathways regulate crucial cellular processes.
  • Dpp is a key TGF-beta superfamily ligand in Drosophila development.
  • Receptor identification is critical for understanding signal transduction.

Purpose of the Study:

  • To identify and characterize the specific genes encoding receptors for the Drosophila dpp signal.
  • To elucidate the distinct roles of these receptors in embryonic patterning and other developmental processes.

Main Methods:

  • Gene identification and characterization.
  • Analysis of gene function in Drosophila embryonic development.
  • Investigation of dpp signaling pathway components.

Main Results:

  • Two genes, thick veins (tkv) and saxophone (sax), were identified as encoding serine/threonine transmembrane receptors.
  • Tkv is essential for patterning the entire embryonic dorsal region.
  • Sax is specifically required for patterning the amnioserosa, the dorsalmost cell fate.

Conclusions:

  • Tkv and Sax function as type I receptors for the Drosophila dpp signal.
  • Differential requirement of tkv and sax in various developmental contexts highlights their specific roles.
  • These receptors appear to directly bind the dpp ligand, a novel observation for type I receptors.

Related Experiment Videos