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Bone marrow involvement by non-Hodgkin's lymphom

W I Lee¹, J H Lee, I S Kim

¹Department of Clinical Pathology & Anatomical Pathology College of Medicine, Kyunghee University, Seoul, Korea.

Journal of Korean Medical Science

|October 1, 1994

Summary

Bone marrow involvement in non-Hodgkin

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Area of Science:

Hematology
Oncology
Pathology

Background:

Non-Hodgkin's lymphoma (NHL) is a heterogeneous group of lymphoid malignancies.
Bone marrow (BM) involvement is a critical prognostic factor in NHL.
Understanding the patterns and incidence of BM involvement is essential for accurate staging and treatment planning.

Purpose of the Study:

To evaluate the incidence and patterns of bone marrow involvement in patients with non-Hodgkin's lymphoma at diagnosis.
To compare the diagnostic accuracy of different bone marrow examination methods.

Main Methods:

Retrospective study of 156 patients diagnosed with non-Hodgkin's lymphoma.
Analysis of bone marrow biopsy, smear, and clot sections for lymphoma involvement.
Histopathological classification and grading of lymphoma subtypes.

Main Results:

35% of NHL patients showed bone marrow involvement at diagnosis.
Diffuse large cell lymphoma was the most common type with BM involvement (30%).
Interstitial and diffuse patterns were most frequent, with extensive marrow space involvement (>76%) in 42% of cases. Bone marrow biopsy demonstrated higher sensitivity (82%) compared to smear (72%) and clot section (69%).

Conclusions:

Diffuse large cell lymphoma is the most common histologic type with bone marrow involvement.
Interstitial and diffuse patterns, along with extensive marrow space involvement, are frequent.
Bone marrow biopsy is the preferred method for detecting lymphoma involvement in the marrow.

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