[S-nitrosothiols and dinitrosothiol iron complexes as a source of nitric oxide in animals]

It was established by EPR method, that S-nitrosocysteine or S-nitrosohomocysteine rapid destructured with releasing nitric oxide (NO) in blood, forming with hemoglobin paramagnetic hemoglobin nitrosyl complexes (Hb-NO). In the presence of exogenous iron in blood dinitrosyl non-heme iron complexes (DNIC) with thiol-containing ligands, i.e. 2,03 complexes arose in blood. These complexes occurred in large quantity if it was introduced to animals low molecular DNIC with cysteine or homocysteine in relation iron/thiol in complexes and solution 1:20 or 1:2. 2,03 complexes in organisms was stable. So, the system of DNIC S-nitrosothiols prevailed the S-nitrosothiols conversation into DNIC.