Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Ligand-dependent ionic conductivity in olfactory cilia]

T Nakamura, T O Sato, S Miiamoto

    Biofizika
    |January 1, 1995
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hepatocyte growth factor is linked by O-glycosylated oligosaccharide on the alpha chain.

    Biochemical and biophysical research communications·1992
    Same author

    Proteolytic activation of a single-chain precursor of hepatocyte growth factor by extracellular serine-protease.

    Biochemical and biophysical research communications·1992
    Same author

    Growth stimulation of rat fetal hepatocytes in response to hepatocyte growth factor: modulation of c-myc and c-fos expression.

    Biochemical and biophysical research communications·1992
    Same author

    Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-beta 1 and glucocorticoids.

    The Journal of biological chemistry·1992
    Same author

    ECM gene expression and its modulation by insulin in diabetic rats.

    Diabetes·1992
    Same author

    Rapid and marked induction of hepatocyte growth factor during liver regeneration after ischemic or crush injury.

    Hepatology (Baltimore, Md.)·1992

    Researchers studied frog olfactory receptor cilia, finding cyclic AMP-gated conductance but not IP3-gated conductance. They detected significant Ca(2+)-gated chloride conductance, suggesting its role in olfactory receptor potential.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Sensory Physiology

    Context:

    • Olfactory receptors in frog cilia are crucial for smell.
    • Understanding ion channel function is key to olfactory signaling.
    • Previous studies identified cyclic AMP-gated channels.

    Purpose:

    • To investigate ion channel activity in frog olfactory receptor cilia.
    • To determine the presence and role of IP3-gated and Ca(2+)-gated channels.

    Summary:

    • Using the whole cilia patch method, cyclic AMP-gated conductance was consistently observed.
    • No significant IP3-gated conductance was detected in the ciliary membrane.
    • A notable Ca(2+)-gated chloride conductance, over 10% of cAMP-gated conductance, was found in most cilia.

    Related Experiment Videos

    Impact:

    • Suggests a significant role for chloride channels in olfactory receptor potential generation.
    • Provides new insights into the complex ion channel mechanisms underlying olfaction.
    • Highlights potential differences in olfactory transduction pathways across species.