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Biodegradation of PLA/GA polymers: increasing complexity

M Vert1, J Mauduit, S Li

  • 1Centre de Recherche sur les Biopolymères Artificiels, URA CNRS 1465 Université Montpellier 1, Faculté de Pharmacie, France.

Biomaterials
|December 1, 1994
PubMed
Summary
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The degradation of polylactic acid and polyglycolic acid (PLA/GA) polymers is complex. Factors like gentamycin and stereoregular sequences influence the faster degradation observed in the interior of large PLA/GA devices.

Area of Science:

  • Polymer Science
  • Materials Science
  • Biomaterials Engineering

Background:

  • Aliphatic polyesters like polylactic acid (PLA) and polyglycolic acid (GA) are widely used in biomedical applications.
  • The degradation of PLA/GA polymers is a critical factor influencing their performance and lifespan.
  • Recent observations indicate heterogeneous degradation, with faster breakdown in the interior of larger devices compared to the exterior.

Purpose of the Study:

  • To review the current understanding of hydrolytic degradation in PLA/GA polymers.
  • To emphasize the complexity of PLA/GA degradation.
  • To highlight the influence of secondary factors on degradation rates and patterns.

Main Methods:

  • Qualitative modeling of diffusion-reaction phenomena.

Related Experiment Videos

  • Incorporation of the autocatalytic effect of carboxylic chain ends into the model.
  • Analysis of secondary factors impacting degradation, including basic loads and polymer microstructure.

    • Main Results:

    • A qualitative model explaining heterogeneous degradation based on diffusion-reaction and autocatalysis is presented.
    • The presence of a basic load, such as gentamycin in PLA matrices, significantly affects degradation.
    • Long stereoregular sequences in poly(DL-lactic acid) macromolecules also influence the degradation process.

    Conclusions:

    • PLA/GA polymer degradation is a multifaceted process influenced by numerous factors.
    • Heterogeneous degradation in large devices is linked to diffusion-reaction dynamics and autocatalysis.
    • Secondary factors like drug incorporation and polymer stereochemistry add further complexity to PLA/GA degradation.