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Low-selenium diet, bone, and articular cartilage in rats
S Sasaki1, H Iwata, N Ishiguro
1Department of Orthopedic Surgery, Nagoya University School of Medicine, Japan.
Nutrition (Burbank, Los Angeles County, Calif.)
|November 1, 1994
Summary
Selenium deficiency in rats leads to Kashin-Beck disease (KBD) pathology, causing cellular changes in cartilage and reduced bone mineral density. This study investigates KBD
Area of Science:
- Biochemistry
- Pathophysiology
- Nutritional Science
Background:
- Secondary osteoarthritis pathophysiology is poorly understood.
- Kashin-Beck disease (KBD) is linked to selenium (Se) deficiency.
Purpose of the Study:
- To investigate the effects of low selenium on bone and cartilage.
- To understand KBD prevention, progression, and treatment.
Main Methods:
- Wistar rats fed a low-selenium diet for 3-11 months.
- Histological and electron microscopic analysis of articular cartilage.
- Measurement of bone mineral density (BMD), serum, and urine selenium levels.
Main Results:
- Low-Se diet induced impaired weight gain and alopecia in rats.
- Electron microscopy revealed chondrocyte degeneration in deep cartilage layers.
- Decreased BMD, serum/urine selenium, and alkaline phosphatase activity observed.
Conclusions:
- Selenium deficiency significantly impacts cartilage and bone health.
- Findings provide insights into Kashin-Beck disease pathophysiology.