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Ascorbic acid is cytotoxic for pediatric tumor cells cultured in vitro
M A Medina1, R García de Veas, L Schweigerer
1Sektion Onkologie/Immunologie, Universitäts Kinderklinik, Ruprecht-Karls-Universität, Heidelberg, Germany.
Biochemistry and Molecular Biology International
|November 1, 1994
Abstract:
2 mM Ascorbic acid has a potent cytotoxic effect on neuroblastoma, osteosarcoma, retinoblastoma, and rhabdomyosarcoma cells cultured in vitro. At a lower concentration (0.2 mM), ascorbic acid remains highly cytotoxic for neuroblastoma, osteosarcoma and retinoblastoma cells, but it has a stimulatory effect on the growth of rhabdomyosarcoma cells.