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Related Experiment Videos

SubtiList: a relational database for the Bacillus subtilis genome

I Moszer1, P Glaser, A Danchin

  • 1Unité de Régulation de l'Expression Génétique, Institut Pasteur, Paris, France.

Microbiology (Reading, England)
|February 1, 1995
PubMed
Summary

SubtiList is a relational database for Bacillus subtilis molecular genetics, managing genome sequences and related data. It facilitates analysis, including codon usage and protein distribution, aiding genomic research.

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Area of Science:

  • Microbiology
  • Bioinformatics
  • Genomics

Background:

  • The international collaborative project aims to sequence the entire Bacillus subtilis chromosome.
  • Managing and analyzing vast amounts of genomic data requires specialized tools.

Purpose of the Study:

  • To create a relational database, SubtiList, for managing and analyzing Bacillus subtilis molecular genetics information.
  • To provide a centralized resource for non-redundant DNA sequences and associated data (genes, proteins) of B. subtilis.

Main Methods:

  • Designed a logical database structure with links between genetic objects.
  • Implemented procedures for data updating and management.
  • Organized the database around known B. subtilis contigs from EMBL data library entries.

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Main Results:

  • Developed a user-friendly interface for easy database consultation.
  • Integrated sequence analysis tools, including rapid protein similarity searching and DNA pattern searching.
  • Performed codon usage analysis and studied protein isoelectric point distribution using the database.

Conclusions:

  • SubtiList provides a consistent and accessible resource for Bacillus subtilis genomic research.
  • The database facilitates advanced analyses, contributing to a deeper understanding of the bacterium's genome.
  • SubtiList is available via anonymous FTP for global scientific access.