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The effect of repeated amphetamine treatment on striatal DA transporter and rotation in rats
1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Brain Research
|December 30, 1994
Abstract:
The effect of repeated amphetamine treatment on the involvement of the striatal DA transporters in rotation behavior was tested in rats. Repeated amphetamine treatment had no effect on [3H]DA uptake or [3H]GBR-12935 binding density. However, unlike the naive rats who rotated away from the striatum with a lower density of DA transporters, rats sensitized to amphetamine rotated toward the striatum with a lower density of DA transporters. These findings imply that repeated amphetamine augments the subcortical involvement in behavioral output.