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Androgen administration to aging men
1Division of Gerontology and Geriatric Medicine, Emory University School of Medicine, Atlanta, Georgia.
Abstract:
Normal aging in men frequently is associated with a decline in serum testosterone levels below the normal range for young adult men. These changes in serum testosterone with age may impact negatively on androgen target organs such as bone, muscle, and psychosexual functioning. Androgen replacement therapy may be of benefit in certain older men, but the potential benefits must be balanced with the potential risks.
Insights
As men age, testosterone levels often decrease, potentially affecting bone, muscle, and sexual function. Androgen replacement therapy may help some older men, but risks must be considered.
Area of Science:
- Gerontology
- Endocrinology
- Men's Health
Background:
- Normal aging in men is frequently linked to decreased serum testosterone levels.
- Declining testosterone can negatively affect androgen-dependent tissues like bone and muscle, and psychosexual functioning.
Purpose of the Study:
- To examine the impact of age-related testosterone decline in men.
- To discuss the potential benefits and risks of androgen replacement therapy in older men.
Main Methods:
- Review of age-related changes in male testosterone.
- Analysis of the effects on target organs and functions.
- Evaluation of androgen replacement therapy considerations.
Main Results:
- Serum testosterone levels often fall below the normal range for young adults in aging men.
- Potential negative impacts on bone, muscle, and psychosexual function are associated with lower testosterone.
Conclusions:
- Androgen replacement therapy might benefit select older men.
- Careful consideration of potential benefits versus risks is crucial for androgen replacement therapy decisions.