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Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity
Published on: November 16, 2017
Prevalence of human astrovirus serotype 4: capsid protein sequence and comparison with other strains
M M Willcocks1, J B Kurtz, T W Lee
1School of Biological Sciences, University of Surrey, Guildford, UK.
Abstract:
Astrovirus serotype 4 has increased in relative prevalence in the Oxford, UK area in 1993. The structural gene of human astrovirus serotype 4 has been sequenced and the results indicate that this protein differs substantially from serotypes 1 and 2. In particular, conservation at the C terminus is greatly reduced. However, amino acid substitutions in this region show a strong conservation in character suggesting that structural or functional constraints operate in this region.
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