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[Stenosing esophagitis in Zollinger-Ellison syndrome]
1Service d'Hépato-Gastroentérologie, Hôpital Bichat-Claude-Bernard, Paris.
Gastroenterologie Clinique Et Biologique
|January 1, 1994
Summary
Zollinger-Ellison syndrome patients with severe esophagitis require prompt, potent acid-suppressing treatment. Early monitoring of treatment efficacy is crucial to prevent esophageal strictures and avoid complications.
Area of Science:
- Gastroenterology
- Gastrointestinal Surgery
Background:
- Zollinger-Ellison syndrome is characterized by hypergastrinemia leading to excessive gastric acid secretion.
- Severe esophagitis can be a complication of Zollinger-Ellison syndrome, potentially leading to esophageal strictures.
Observation:
- Three patients with Zollinger-Ellison syndrome presented with severe esophagitis and developed intractable esophageal strictures.
- Two patients required esophago-gastrectomy, and one needed repeated esophageal dilatations due to strictures.
Findings:
- Prompt and aggressive antisecretory treatment is recommended for esophagitis in Zollinger-Ellison syndrome patients.
- Parenteral administration of antisecretory agents may be necessary for severe cases.
- Regular monitoring of treatment efficacy, including basal acid output, is essential.
Implications:
- Early and effective management of acid hypersecretion can prevent severe esophageal complications.
- Avoiding unjustified treatment discontinuation and unnecessary gastric intubations is advised.
- This approach aims to improve outcomes and reduce the need for invasive procedures in affected patients.