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Treatment of experimental endocarditis due to multidrug resistant Enterococcus faecium with ciprofloxacin and
J M Quale1, D Landman, N Mobarakai
1Department of Medicine (111E), Brooklyn Veterans Administration Medical Center, New York 11209.
The Journal of Antimicrobial Chemotherapy
|November 1, 1994
Abstract:
The effectiveness of ciprofloxacin and/or novobiocin therapy was assessed for experimental endocarditis caused by three strains of Enterococcus faecium resistant to ampicillin, vancomycin, and aminoglycosides. Rabbits with endocarditis caused by two of the strains had a significant decrease in bacterial counts in vegetations when treated with both antibiotics. Further studies using combination therapy with ciprofloxacin plus novobiocin for multidrug resistant strains of E. faecium are warranted.