Related Experiment Videos
Inflammatory pseudotumour of lymph nodes
N E New1, P W Bishop, M Stewart
1Department of Pathology, Christie Hospital NHS Trust, Withington, Manchester.
Journal of Clinical Pathology
|January 1, 1995
Summary
Inflammatory pseudotumour of lymph nodes is a rare, benign lesion that can mimic cancer. Recognizing its distinct histological features is crucial to avoid misdiagnosis.
Area of Science:
- Pathology
- Immunohistochemistry
- Oncology
Background:
- Lymph node lesions can present diagnostic challenges.
- Some benign conditions may mimic neoplastic processes.
Purpose of the Study:
- To detail the clinical, histological, and immunohistochemical characteristics of four cases of inflammatory pseudotumour of lymph nodes.
- To differentiate this benign lesion from neoplastic conditions.
Main Methods:
- Analysis of four cases of inflammatory pseudotumour of lymph nodes.
- Utilized conventional staining (H&E, PAS, reticulin, Ziehl-Neelsen).
- Employed immunohistochemical techniques with a panel of antibodies (CD3, L26, CD15, CD21, CD30, KP1, MAC 387, vimentin, alpha SMA, HHF-35, D33, CD34, S100).
Main Results:
- The lesion shows spindle cell proliferation expanding lymph node stroma.
- Associated infiltrates include plasma cells, small lymphocytes, macrophages, neutrophils, and eosinophils.
- Variable fibrosis and vascular changes are observed.
Conclusions:
- Inflammatory pseudotumour of lymph nodes is an uncommon benign reactive pattern.
- Histological awareness is key to prevent misdiagnosis as a neoplastic or malignant process.