Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lessons learned from a prospective meta-analysis

S E Margitić1, T M Morgan, M A Sager

  • 1Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC 27157-1063, USA.

Journal of the American Geriatrics Society
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standardizing time-to-event reporting in single-arm BCG-unresponsive registration trials: a case for Kaplan-Meier.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

The impact of cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline.

medRxiv : the preprint server for health sciences·2025
Same author

Durable benefit from poly(ADP-ribose) polymerase inhibitors in metastatic prostate cancer in routine practice: biomarker associations and implications for optimal clinical next-generation sequencing testing.

ESMO open·2024
Same author

Prognostic value of plasma circulating tumor DNA fraction across four common cancer types: a real-world outcomes study.

Annals of oncology : official journal of the European Society for Medical Oncology·2022
Same author

Corrigendum to "Nomogram Predicting Bladder Cancer-specific Mortality After Neoadjuvant Chemotherapy and Radical Cystectomy for Muscle-invasive Bladder Cancer: Results of an International Consortium" [Eur Urol Focus 2021;7:1347-54].

European urology focus·2022
Same author

Developing a Patient-Centered Model of Prostate Cancer Care: Patient Satisfaction With a Survivorship Program Embedded in Urologic-Oncologic Care.

Urology·2021
Same journal

Utilization Patterns Among Heterogeneous Subgroups of Homebound Older Adults: A Latent Class Analysis.

Journal of the American Geriatrics Society·2026
Same journal

Off-Label Initiation of Gabapentin and Valproic Acid Among Long-Stay Nursing Home Residents With and Without Dementia.

Journal of the American Geriatrics Society·2026
Same journal

The DOAC-FRAIL Study-Same Dose, Different Story: Prevalence of Deviant Direct Oral Anticoagulant Levels in Nursing Home Residents.

Journal of the American Geriatrics Society·2026
Same journal

Practice Environment and Job Outcomes Among Primary Care Nurse Practitioners Caring for Patients With Dementia.

Journal of the American Geriatrics Society·2026
Same journal

Anticholinergic Medication Use in Veterans Affairs Long-Term Care Residents: Clinical Patterns and Opportunities for Deprescribing.

Journal of the American Geriatrics Society·2026
Same journal

Perioperative Transfusion Trigger Score Versus Restrictive Transfusion in Older Non-Cardiac Surgery Patients: A Multicenter Randomized Controlled Trial.

Journal of the American Geriatrics Society·2026
See all related articles

Planning a prospective meta-analysis (PMA) for older hospitalized patients requires careful consideration. This approach offers advantages over individual trials but presents unique challenges in data collection, coordination, and maintaining scientific integrity.

Area of Science:

  • Geriatric Medicine
  • Clinical Trials Methodology
  • Health Services Research

Background:

  • Hospitalized older adults are at high risk for functional decline.
  • Existing interventions show varied effectiveness, necessitating pooled data analysis.
  • The Hospital Outcomes Project for the Elderly (HOPE) aimed to synthesize evidence on interventions to reduce functional decline.

Purpose of the Study:

  • To detail the planning and execution of a prospective meta-analysis (PMA) for interventions targeting functional decline in hospitalized elderly.
  • To identify and discuss the unique challenges and lessons learned from the HOPE PMA.

Main Methods:

  • A prospective meta-analysis (PMA) design was employed, pooling data from concurrently run clinical trials.
  • Data were collected and analyzed by a central Data Coordinating Center across six healthcare sites.

Related Experiment Videos

  • Participants were acutely ill hospitalized individuals aged 65-75 years receiving various geriatric interventions.

    • Main Results:

    • The PMA design facilitated the compilation of data from distinct yet related interventions.
    • Coordination of common outcome data collection and analysis was managed by the Data Coordinating Center.
    • Interventions included exercise, physical therapy, multidisciplinary geriatric units, post-discharge care, nursing programs, and delirium management.

    Conclusions:

    • Prospective meta-analyses offer advantages over independent trials and retrospective analyses.
    • Key challenges include maintaining scientific integrity, achieving consensus on data collection and quality, defining the coordinating center's role, and establishing data ownership and publication policies.
    • Addressing these design and operational challenges proactively is crucial for successful PMA implementation.