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A technique for studying the function of an isolated, perfused and ventilated lung in a rat model
D N Hopkinson1, N J Odom, R M Eloakley
1Department of Cardiothoracic Surgery, Wythenshawe Hospital, Manchester, UK.
Laboratory Animals
|January 1, 1995
Abstract:
We describe a technique which allows perfusion of an isolated, ventilated rat lung with an extracorporeal veno-venous circuit from a support animal. This model provides stable and reliable function of the isolated lung for up to 3 h, thus overcoming some of the disadvantages of previous models. It may prove a potentially useful model for assessing ischaemic lung injury.