Prognostic indicators for in vitro fertilization success

To examine possible prognostic indicators for success and multiple pregnancy in a free-standing in vitro fertilization program, a chart review study based on 160 oocyte retrievals was undertaken. Evaluated factors included the woman's age, diagnosis, baseline follicle-stimulating hormone levels, peak estradiol levels, estradiol patterns, cycle day of oocyte retrieval, oocyte quality, and number of embryos transferred. Factors associated with a higher pregnancy rate and a higher multiple pregnancy rate may include age less than or equal to 35; diagnosis of unexplained infertility; pattern A early estradiol response; oocyte retrieval on cycle day 16; 2 or fewer fractured oocytes at retrieval; and transfer of 4 or more embryos.