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[Sideropenic anemia and celiac disease]

R Lazzari1, A Collina, G Arena

  • 1Clinica Pediatrica III, Università di Bologna, Italia.

La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
|November 1, 1994
PubMed
Summary

Antigliadin antibodies (AGA) aid in diagnosing coeliac disease (CD), including atypical forms. Screening for CD is crucial in patients with unexplained iron deficiency anemia, as it can be an isolated symptom.

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Area of Science:

  • Gastroenterology and Hepatology
  • Pediatric Hematology
  • Immunology

Context:

  • Coeliac disease (CD) diagnosis has increased with Antigliadin Antibodies (AGA) screening, revealing more monosymptomatic and atypical cases.
  • Iron deficiency anemia is a common manifestation of CD, appearing alone or with other symptoms.

Purpose:

  • To determine the incidence of iron deficiency anemia in diagnosed coeliac disease patients.
  • To assess the prevalence of coeliac disease in pediatric patients with unexplained, iron-refractory anemia.

Summary:

  • 48.5% of 212 coeliac patients presented with hypochromic, microcytic anemia.
  • 6.2% of 96 pediatric patients with unexplained anemia were diagnosed with CD based on positive AGA, Antiendomysium Antibodies (AEA), and jejunal biopsy.

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Impact:

  • Confirms a high association between coeliac disease and iron deficiency anemia.
  • Highlights the importance of screening for coeliac disease in patients with unexplained hypochromic anemia to identify this monosymptomatic presentation.