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[Use of ifosfamide in multidrug therapy of small cell lung carcinoma]
1Kliniki Chemioterapii Centrum Onkologii Instytutu im. M. Skłodowskiej-Curie Oddział w Krakowie.
Abstract:
Own concept of small cell lung carcinoma (SCLC) chemotherapy with multidrug regimen including ifosfamide, adriamycin, and etoposide is presented. In the pilot trial, 67% of remissions in patients with localized, and 33% in patients with disseminated neoplastic process were achieved. Proposed therapy has moderate toxicity, markedly lower than that of the regimen including cis-platin. No nephrotoxicity is worth emphasizing. The authors suggest that proposed regimen may be of value in patients in whom combined chemo- and radiotherapy is foreseen.
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