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Related Experiment Videos

Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain

B Brugg1, Y L Dubreuil, G Huber

  • 1Université P. & M. Curie, Institut des Neurosciences (Unité de Recherche Associée 1488, Centre National de la Recherche Scientifique), Paris, France.

Proceedings of the National Academy of Sciences of the United States of America
|March 28, 1995
PubMed
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Inflammation, triggered by lipopolysaccharide (LPS), alters beta-amyloid precursor protein (APP) expression in mouse brains, potentially linking inflammatory processes to neurodegeneration and Alzheimer disease.

Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Alzheimer disease involves genetic and environmental factors impacting beta-amyloid precursor protein (APP) expression, peptide deposition, and neuronal loss.
  • Inflammatory processes, triggered by events like head injury or infection, are implicated in Alzheimer disease development.

Purpose of the Study:

  • To investigate the in vivo effects of peripheral inflammatory stimulation on APP expression in the mouse brain.
  • To examine the role of inflammation in APP isoform changes and neurodegeneration, particularly in the context of the staggerer mouse mutant.

Main Methods:

  • Peripheral stimulation of mice with lipopolysaccharide (LPS) to induce inflammation.
  • Analysis of inflammatory cytokine mRNA levels (interleukin 1 beta, interleukin 6) and APP isoform expression in brain tissues (cerebellum, cerebral cortex).

Related Experiment Videos

  • Comparison of APP expression patterns between wild-type mice and staggerer mouse mutants.

    • Main Results:

    • LPS stimulation induced a transient increase in inflammatory cytokine mRNAs (interleukin 1 beta and interleukin 6).
    • APP expression changes, specifically a decrease in APP-695 and an increase in KPI-APP isoforms, were observed in the cerebellum but not the cerebral cortex.
    • Staggerer mice showed elevated basal interleukin mRNA levels and an increased KPI-APP/APP-695 ratio, which were exacerbated by LPS stimulation.

    Conclusions:

    • Acute and chronic inflammatory processes significantly influence APP expression patterns.
    • Changes in APP isoforms, particularly the increase in KPI-APP, may be associated with neurodegenerative processes.
    • Inflammation is a key factor in the alterations of APP expression linked to neurodegeneration.