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Updated: Aug 9, 2026

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
Published on: July 3, 2015
Cell inactivation, mutation and DNA strand-break induction by gamma-rays at very low temperatures
Abstract:
Cell inactivation, mutation and DNA strand-break induction by gamma-radiation have been investigated at very low temperatures (-78 degrees C, -196 degrees C, and -268 degrees C). In Escherichia coli Ymel, lacI+-->lacI- and Salmonella typhimurium TA102, his--->his+ dose-modifying factors determined for low radiation doses are similar for both mutation induction and cell inactivation. The sensitivity of repair-deficient strains E. coli polA- and E. coli recA- was also reduced at low temperature to a comparable extent. This suggests that the lesions which are responsible for cell inactivation and mutagenesis could be strongly mutually related and/or that different types of lesions which are responsible for cell inactivation and mutation induction in bacteria are reduced at low temperature to the same or similar extent. Likewise, a lower yield of DNA strand breaks in plasmids irradiated at low temperature was observed.
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